Colleen Cutcliffe, PhD: Microbiome Science, GLP-1, and Next-Gen Probiotics That Actually Deliver

Colleen Cutcliffe, PhD, co-founder and CEO of Pendulum, joins us to demystify the microbiome and explain what “next-generation probiotics” really are. Colleen shares how DNA sequencing opened the door to mapping the gut, why Akkermansia is a keystone strain for gut integrity and GLP-1 stimulation, and how Pendulum approaches clinical evidence with randomized, double-blind trials. She walks through what to look for on labels (enteric coating and time-delayed release), when and why people become depleted in key strains, and the real-world use cases for metabolic health, GI stability, travel, stress, aging, and sport performance.

You’ll also hear the personal story that fueled Pendulum’s mission, how food choices like high-polyphenol and high-fiber options feed a healthier microbiome, and Colleen’s take on pairing natural tools with medications when appropriate. We wrap with leadership lessons, building trust in a crowded supplement market, and one big misconception about gut health she hopes more people understand.

Takeaways:
• Next-gen probiotics target more than bloating
• Akkermansia supports gut lining, tight junctions, and GLP-1
• Delivery tech matters as much as what’s inside
• Polyphenols and fiber are powerful prebiotics
• Evidence and education build lasting trust

Tune in to learn how smarter microbiome choices can support metabolism, energy, and overall health.